Probiotic + Metabolism Strips are built for a different mechanism than the capsule probiotics you grew up with. Instead of trying to colonize your gut — a route where stomach acid kills most of what you swallow before it can reach the intestine — these strips dissolve under your tongue and deliver Bifidobacterium lactis directly to the oral microbiome, with the polydextrose prebiotic fiber along for systemic postbiotic effects. Two real mechanisms. Both bypass the stomach.
The format matches the goal. A 30-second dissolve, no water needed, mixed berry flavor, and a strip pouch you can keep in a wallet or a desk drawer. If you want a traditional gut-colonization probiotic, you should take an enteric capsule — we don't sell that, and we're upfront about it. What we make is a sublingual probiotic + postbiotic stack designed to support oral microbiome health and metabolic balance as part of a daily routine.*
Mixed berry flavored, naturally sweetened with monk fruit and stevia, no added sugar, vegan, halal-compatible by ingredient profile, made in the US in a cGMP-certified facility. One strip per day. That's the routine.
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10 Billion CFU Bifidobacterium lactis — one clinically-studied strain at a real maintenance dose. No 50-strain marketing theater.
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50 mg Polydextrose prebiotic — feeds the good bacteria you already have. GRAS-recognized, gentle on the gut.
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Shelf-stable. No refrigeration. — the pullulan strip matrix stabilizes the bacteria at room temperature. Travel-friendly.
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Mixed berry, 30-second dissolve — no capsule fatigue, no water, no forgetting the bottle in the fridge.
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~$1/day — cheaper than the four-brand probiotic switcher that never sticks. $29.99 tin, 30 strips.
You didn't come here by accident.
Your stomach hasn't been comfortable in a long time. Long enough that you've stopped noticing when it feels okay. You've tried the well-designed probiotic capsules. You've tried the kombucha era, and the bone-broth era, and the low-FODMAP era. Some helped a little. None of them held.
Here's what I think is happening.
Two things layered on top of each other. First: most oral probiotic CFU is killed by stomach acid before reaching your gut — peer-reviewed studies put survival somewhere in the 10–40% range depending on strain. Most of what a capsule promises on the label doesn't arrive where it's meant to work. Not because the product is bad — because the delivery is fighting biology.
Second, and this is newer: a wave of 2025 research has been mapping the oral–gut microbiota axis — a two-way relationship between the microbial community in your mouth and the one in your gut. What that means practically is that the oral microbiome is a real, distinct biome, and a sublingual film can target it directly, without anything needing to survive stomach acid at all.
Here's what I made for that.
Probiotic + Metabolism is a sublingual film — Bifidobacterium lactis delivered to the oral microbiome, where the emerging science says it belongs, plus a polydextrose prebiotic fiber to feed beneficial strains and support systemic postbiotic effects. Two real mechanisms. Both bypass the stomach.
Under the tongue in about 30 seconds. Different mechanism, different door. If you want a traditional gut-colonization probiotic, take an enteric capsule — we don't sell that, and we're upfront about it. What this is: a sublingual probiotic + prebiotic built for the biome a capsule can't reach.
— Brandon, XYNE founder
"Do sublingual probiotics even reach the gut?"
Yes — the strip dissolves in your mouth, and you swallow the bacteria with saliva. We're not claiming sublingual absorption of the bacteria themselves (that would be unusual — probiotics need to reach the gut to work). The strip format is about convenience: no refrigeration, no capsule fatigue, no forgetting the bottle at home. The Bifidobacterium lactis reaches your gut the same way it would from a capsule — through the digestive tract.
"Is 10 Billion CFU enough?"
It's a standard maintenance dose. Some multi-strain formulas advertise 50–100B CFU, but higher isn't automatically better — many of those are already dead by the time they reach your gut. XYNE is one clinically-studied strain (Bifidobacterium lactis) with published data at this dose range, plus 50 mg of polydextrose prebiotic fiber to feed it. Quality over quantity.
"I've been burned by probiotic brands before."
Same. Most probiotic brands are dead by the time they reach your stomach — capsules stored on a warm shelf for six months don't do much. XYNE is a strip you take fresh from a sealed tin, with a pullulan matrix that stabilizes the bacteria at room temperature. If you don't notice a difference in your first 30-day tin, email me and I'll make it right.
Frequently asked
Do XYNE strips bypass the stomach?
For most XYNE strips, yes — the actives absorb through the sublingual tissue. Probiotic + Metabolism is the honest exception: the bacteria dissolve in your mouth, and you swallow them. They reach the gut through the digestive tract, because probiotics need to reach the gut to work. The strip format is about convenience — no refrigeration, no capsule fatigue — not sublingual absorption of the bacteria themselves.
How fast does a Probiotic + Metabolism strip dissolve?
About 30 seconds on the tongue. Mixed berry flavor, naturally sweetened with monk fruit and stevia, no added sugar.
Do I need refrigeration?
No. The strip's pullulan matrix stabilizes the bacteria at room temperature. Unlike traditional refrigerated probiotic capsules, you can keep a tin in a desk drawer, a travel bag, or a nightstand and it stays viable through the printed date.
Is 10 billion CFU enough?
For general daily maintenance, yes — it's a well-studied dose range for Bifidobacterium lactis. If you're recovering from a course of antibiotics or managing a specific gut condition, talk to your doctor about a higher-dose targeted multi-strain formulation.
Can I take this with antibiotics?
Space them out. Antibiotics kill both harmful and beneficial bacteria — taking a probiotic within a few hours can waste the strip. If your clinician has you on antibiotics, take the antibiotic in the morning and the strip 4–6 hours later, or wait until the antibiotic course is complete.
Is polydextrose safe?
Yes. Polydextrose is a well-studied soluble prebiotic fiber, generally recognized as safe (GRAS) by the FDA. At 50 mg per strip, it's a maintenance dose — not the high-gram doses that some fiber supplements use, which are what typically trigger GI discomfort.
Ingredients: Polydextrose (50mg), Bifidobacterium lactis 37.5mg (10 Billion CFU), Pullulan, Cellulose, Mannitol, Mixed berry flavor, Sunflower Lecithin, Monk fruit extract, Erythritol, Medium chain triglycerides, Malic acid, Steviol glycoside
Flavor: Mixed berry
Manufactured: cGMP-certified facility — designed in the USA
Product amount (oz/lbs/g): 30 Strips / 1.2 oz / 0.07 lbs / 33 g
Gross weight (oz/lbs/g): 2 oz / 0.13 lbs / 60 g
Suggested use: Place one oral strip on your tongue and allow it to dissolve before swallowing. Take one oral strip anytime.
Warning: Keep out of reach of children. Do not use if the safety seal is damaged or missing. Store in a cool, dry place.
Caution: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
